16/06/2026
Jeff Kaufman got into effective altruism before it even had a name. From 2009 to 2022, he and his wife, Julia Wise, donated 50% of their income, giving away over $2 million. Then, a conversation with someone from 80,000 Hours changed his trajectory. Jeff felt he could do more by applying his skills directly to help prevent catastrophic pandemics, rather than focusing on donations.
Today, Jeff leads SecureBio Detection (formerly the Nucleic Acid Observatory), a project working to detect stealth pandemics before they spread beyond our ability to respond.
In this video, Jeff explains how metagenomic sequencing can catch pathogens we aren't even looking for, why stealth pandemics represent one of the most serious biological risks to humanity, and what it would take to remove this risk entirely. "I think it is achievable to get to where stealth pandemics are not a feasible way to attack humanity, where if someone tried it, we would catch it and they would not succeed."
• See more impact stories like this one: effectivealtruism.org/stories
• Learn more about SecureBio Detection: securebio.org/detection
• Learn more about effective altruism: effectivealtruism.org
• Inspired? Take Action: effectivealtruism.org/take-action
Chapters:
00:00 – Biosecurity and Pandemic Detection
00:56 – SecureBio Detection (Nucleic Acid Observatory)
01:28 – How Metagenomic Sequencing Works
02:13 – Why Stealth Pandemics Are a Top Priority
03:04 – From Earning to Give to Direct Work
05:32 – What Success Looks Like: Taking Stealth Pathogens Off the Table