Centre-for-Chemical-Biology-USM

25/10/2023

25/05/2022

59th USM Convocation Ceremony..

24/05/2022

Expert service and guidance on insect specimen identification.
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24/05/2022

RESEARCH HIGHLIGHTS - Multiple Mechanisms Conferring Broad-Spectrum Insecticide Resistance In The Tropical Bed Bug (Hemiptera: Cimicidae)
by Kai Dang, Stephen L Doggett, Xin-Yeng Leong, G Veera Singham, Chow-Yang Lee

The modern resurgence of the common (Cimex lectularius L.) and tropical bed bugs (C. hemipterus [F.]) is thought to be primarily due to insecticide resistance. While there are many reports on insecticide resistance mechanisms in C. lectularius, such information in C. hemipterus is limited. We examined dichloro-diphenyltrichloroethane (DDT), malathion, deltamethrin, permethrin, lambda-cyhalothrin resistance, and the underlying mechanisms in several C. hemipterus strains (Australia: Queensland [QLD-AU]; Malaysia: Kuala Lumpur [KLMY], Tanjung Tokong [TT-MY], Christian [CH-MY], and Green Lane [GL-MY]). We used a surface contact method, synergism studies (utilizing piperonyl butoxide [PBO], S,S,S-tributyl phosphorotrithioate [DEF], and diethyl maleate [DEM]), and molecular detection of kdr mutations. Results demonstrated that all C. hemipterus strains possessed high resistance to DDT and the pyrethroids and moderate to high resistance to malathion. Synergism studies showed that deltamethrin resistance in all strains was significantly (P 12 h) than those (≤1 h) with other combinations. M918I + L1014F mutations most likely conferred super-kdr characteristic toward pyrethroids and DDT in C. hemipterus.

Link: https://doi.org/10.1093/jee/toab205

18/05/2022

Hi All..

An Announcement & please take note that:

Centre for chemical biology website (http:///www.ccb.usm.my) is temporarily down for maintenance

Centre For Chemical Biology,  Universiti Sains Malaysia,  Sains@USM, Blok B No. 10, Persiaran Bukit Jambul 11900 Bayan Lepas Pulau Pinang MalaysiaTel : +604-653 5500 | Fax : +604-653 5514 | emel : [email protected]   

11/05/2022

Come join us.. Intake of MSc student in Microbiology & Molecular Biology

For further information on this project, please click on the following link: https://bit.ly/38oVKHs

10/05/2022

RESEARCH HIGHLIGHTS - The Vibrio-Predatory Filamentous Bacteria Effectively Removed Shrimp Pathogenic Vibrio In Vitro by Yeoh, H.I., Izzatty, R., Furusawa, G., Amirul, A.-A.A., Shu-Chien, A.C., Sung, Y.Y.

Acute hepatopancreatic necrosis (AHPND) caused by pathogenic Vibrio parahaemolyticus strains (VpAHPND) and other Vibrio spp. the disease has resulted in significant economic losses in shrimp aquaculture in many countries including Malaysia. Several biocontrol agents on VpAHPND, such as probiotics, vaccination, and bioflocs, have been proposed. However, each of these alternatives has limitations in removing VpAHPND from aquatic environments. Ms. Hao Ing Yeoh and Ms. Rosli Izzatty, under the supervision of Dr. Go Furusawa, assessed the potential of Vibrio-predatory filamentous bacteria (VPFB) as a novel biocontrol agent on VpAHPND.

Three VPFBs from the genera Saprospira (CCB-QB6) and Aureispira (CCB-E and F) were isolated from seagrass habitat in Penang, Malaysia. The VPFBs exhibited predation on VpAHPND and other Vibrio spp. including V. owensii, V. harveyi, and V. alginolyticus. The VpAHPND and VPFB co-culture experiments demonstrated reduction of VpAHPND cell number to less than 1 x 104 cells/ml from an initial (1 x 107 cells/ml) within 24 h of introducing strain E or F. Scanning electron microscopy revealed that VPFBs formed cell aggregates with VpAHPND within a few minutes by attachment on the cell surface of VPFBs cells before the Vibrio cells destroyed. These findings revealed that VPFBs have the potential to be used as a biocontrol agent for removing VpAHPND in shrimp aquaculture.

Link: doi.org/10.1016/j.aqrep.2021.100910