10/08/2026
CTN+ researcher Dr. Elisabeth McClymont is the first author on the longest study to date of the in women living with HIV. The study (CTN 236) finds the vaccine offers long-term protection.
Human papillomavirus (HPV) causes 99% of all cervical cancer. Women living with HIV have higher rates of HPV infection and associated diseases. Women living with HIV have higher rates of human papillomavirus (HPV) infection and associated diseases. This makes understanding the impact of HPV vaccines on this population vital for eliminating cervical cancer.
• This study recruited 228 girls and women with HIV from clinics across Canada.
• Participants received 3 doses of the quadrivalent HPV vaccine at 0, 2, and 6 months.
• Every 6–12 months, participants underwent testing to see how their immune system was responding and if they had been infected with HPV.
• The study ran from July 1, 2008, to June 27, 2019.
• Researchers found that the HPV vaccine produced a strong and sustained immune response against HPV.
• They also found low rates of HPV among participants who received all 3 vaccine doses, and did not already have the strains of HPV targeted by the vaccine.
This study shows how HPV vaccination is crucial for lowering HPV transmission and cervical cancer rates among women and girls living with HIV.