13/05/2026
The eradication of smallpox in 1980 remains one of medicine’s greatest triumphs 🧪
For centuries, smallpox was among the world’s deadliest diseases. It was highly contagious, disfiguring, and often fatal. It began with fever, pain, and crushing fatigue before erupting into blistering rashes that left many scarred or blind for life.
These illustrations are taken from a manuscript called 'The Essentials of Smallpox' (痘疹精要) which reveals the devastating impact of the disease in Edo-period Japan (1603-1867).
The illustrations document different symptoms of smallpox, and some images even have holes gouged into the paper to capture the severity of the scarring.
Long before modern vaccines existed, societies across China, India, the Ottoman Empire, and Japan practiced forms of inoculation by deliberately exposing people to smallpox material to build up their immunity.
In 1796, the physician Edward Jenner changed the course of medicine by using cowpox to build immunity against smallpox, creating the world’s first modern vaccine and a safer path to protection.
Thanks to vaccinations, smallpox became the first human disease ever eradicated, a testament to science, medicine and human resilience.
[Alt text: Six Japanese illustrations on yellowed parchment depicting the effects of smallpox on the human body. The images show different stages of the disease, from early pink rashes resembling chickenpox to swollen blisters filled with pus, and finally permanent pockmarked scarring. Several illustrations focus on the male torso, with one figure shown scratching his skin, conveying the intense discomfort and pain smallpox caused.]
Credit: MS Japanese 63. Source: Wellcome Collection.