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Sociedad Mexicana de Proteómica

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Sociedad Mexicana de Proteómica

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Organización Civil sin fines de lucro, cuyo objetivo es impulsar el desarrollo de la investigación proteómica y metabolómica en México usando como herramienta fundamental la Espectrometría de Masas.

19/10/2026

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Nε-Carboxymethyllysine (CML) is one of the most studied advanced glycation end products and is used as glycation marker in foods. To prevent its artifactual formation during sample preparation, CML determination protocols commonly include reduction step prior to acid hydrolysis. However, the effectiveness of this approach may depend on the glycating agents present in the sample. The aim of this study was to evaluate the impact of sodium borohydride reduction on CML determination in pork meat when glyoxylic acid (GA) acts as glycating agent. Raw and cooked pork loin samples were incubated with different amounts of GA and subsequently processed for CML analysis either with or without reduction. CML was quantified by high-performance liquid chromatography-electrospray ionization-ion trap tandem mass spectrometry. In samples not supplemented with GA, NaBH4 treatment increased CML concentrations from 23.2 ± 0.6 to 26.0 ± 1.3 µg g⁻¹ in raw meat and from 24.8 ± 1.1 to 29.7 ± 0.8 µg g⁻¹ in cooked meat. GA supplementation without reduction resulted in modest but significant increases in CML concentration (maximum 50% relative to controls). In contrast, samples subjected to sodium borohydride reduction exhibited a pronounced GA dose-dependent increase in CML levels, reaching up to 200-fold higher values compared to samples without added GA. Mild acidification (pH 2–4) failed to suppress this effect and, under reducing conditions, further promoted CML formation, particularly at pH 2. These findings demonstrate that NaBH4 treatment can convert GA-derived imine intermediate into CML, causing overestimation of native CML concentrations and current reduction-based pretreatment protocols for CML analysis require critical re-evaluation to avoid analytical bias.

15/10/2026

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Postharvest UVB treatment was evaluated as a sustainable strategy to improve the functional value of Amaranthus hybridus leaf powder and its use in nixtamalized maize tortillas. Untreated (AP) and UVB-treated amaranth powders (SAP) were produced and incorporated into tortillas at 7.5% substitution. UVB treatment increased L-phenylalanine in SAP and selectively changed its phenolic profile. After tortilla processing, tortillas containing SAP (SAT) showed the highest phenolic content among tortilla samples, with 3.29-fold more quantified phenolics than tortillas containing AP (AT) and a 10.5-fold increase in rutin. Amaranth incorporation improved protein and dietary fiber contents, reduced rapidly digestible starch, and lowered the predicted glycemic index. SAT also showed the highest cellular antioxidant activity and nitric oxide inhibition. The enriched tortillas maintained microbiological quality, low anti-nutritional burden, acceptable physical properties, and moderate sensory acceptability. These results support UVB-treated amaranth powder as a sustainable ingredient for functional maize-based staple foods.

13/10/2026

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Hepatocellular carcinoma (HCC) remains a major global health burden. We have recently demonstrated the synergistic cytotoxicity elicited by the combination of loratadine, raloxifene, and sorafenib in liver cancer cells. In this study, we investigated the potential mechanistic basis of this novel multi-drug regimen by identifying candidate protein targets of the three drugs. Potential protein targets of each drug were identified using the Drug Affinity Responsive Target Stability (DARTS) assay in protein extracts from the HCC cell line HuH7, and molecular docking was performed to predict binding modes and explore the structural feasibility of these drug–target interactions. Bioinformatics analyses were conducted to predict biological functions, molecular interactions, and clinical relevance. We identified 147 potential candidate DARTS-stabilized proteins for loratadine, 191 for sorafenib, and 157 for raloxifene; a proportion of these candidate proteins maintained a statistically significant association with overall survival in HCC patients: 20.14% for loratadine, 22.93% for raloxifene, and 24.47% for sorafenib. Cross-referencing with public databases confirmed several previously documented targets—complementing our experimental approach—while revealing numerous previously unreported target candidates. Docking analyses predicted favorable binding interactions between the drugs and several proteins, such as the putative complex between loratadine and N-glycanase 1 (NGLY1), whose expression correlates with reduced overall survival in HCC patients. Functional enrichment analysis showed that several targets are involved in hallmarks of cancer. Clinically relevant candidate targets of loratadine, raloxifene, and sorafenib were identified. However, as these candidate protein targets were identified exclusively in HuH7 cells, they may not fully generalize across all HCC models without further validation. Nevertheless, our results suggest that loratadine, raloxifene and sorafenib modulate key pathways involved in tumorigenesis. These findings strengthen the use of this combination as a promising therapeutic strategy for HCC and provide new opportunities for the identification of novel targets, prognostic markers, and molecular vulnerabilities suitable for pharmacological intervention in HCC and other malignancies and diseases.

09/10/2026

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Cryopreservation is an effective strategy for the long-term conservation of plant germplasm. However, the metabolic responses of cryoderived plants under ex vitro conditions have been little studied. This work evaluates the proteomic profile of Vanilla planifolia plants regenerated from shoot tips recovered after cryopreservation using the Droplet-vitrification (D-V), D-Cryoplate (D-Cp), and V-Cryoplate (V-Cp) methods. The plants were maintained under greenhouse conditions for four years, and protein expression was analyzed using nano-LC-MS/MS. A total of 3523 proteins were identified, and 1019 showed differential expression compared to non-cryopreserved control plants. Nine proteins were consistently upregulated across all cryopreservation methods, including chalcone-flavanone isomerase, Glucose-Methanol-Choline oxidoreductase, calreticulin, glutamine synthetase, 3-ketoacyl-CoA synthase, pectinesterase, BAHD acyltransferase, α/β-hydrolase, and peroxidases. These proteins are associated with stress protection, primary metabolism, cell wall remodeling, and lipid and nitrogen metabolism. Conversely, down-regulation was observed in EG45-type expansin and in proteins containing RNA recognition motifs involved in growth regulation. Functional enrichment analysis revealed enhanced photosynthetic capacity and structural reinforcement in cryoderived plants compared to non-cryopreserved control plants. Among the procedures evaluated, the D-Cp technique, followed by the D-V technique, proved to be the most effective, demonstrating that cryopreservation enabled stable metabolic reprogramming during the greenhouse development of V. planifolia plants.

07/10/2026

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Abstract
Cuachalalate bark (Amphipterygium spp.), relevant in Mexican herbal medicine for its gastroprotective, and anti-Helicobacter pylori effects, as well as its reported antiproliferative/cytotoxic and antitumor effects, lacks systematic studies on bioactive metabolites influenced by biotic and abiotic factors. This study used untargeted 1H NMR metabolomics to characterize chemical profiles, quantify anacardic acids and 3α-hydroxymasticadienoic acid (3α-HMDA) according to climatic season, tree s*x, and bark type (stem or branch), and evaluate anti-H. pylori activity. Three hundred sixty samples from 40 juvenile-adult A. adstringens trees were collected in Chiautla de Tapia, Puebla, Mexico. Principal component analysis (PCA) and partial least squares-discriminant analysis (PLS-DA) of chemical profiles discriminated variations by collection month, tree s*x, and bark type. Only minor variations in biomarker concentrations were recorded in specific cases (e.g., July > September/December [3α-HMDA: 28.9 vs. ∼19 mM; anacardic acids: 18.7 vs. ∼12 mM]; males > females in July [19.6 vs. 17.8 mM; 30.3 vs. 23.6 mM]; stem > branch in December [15.7 vs. 9.6 mM; 20.8 vs. 15.1 mM] and September [14.3 vs. 10.4 mM; 20.6 vs. 17.1 mM]), with no significant overall differences by seasonality, s*x, or bark type. Despite some differences in biomarker concentrations in specific cases, anti-H. pylori activity remained stable (59.4 ± 14.6% at 0.125 mg/mL; 82.7 ± 11.8% at 0.25 mg/mL; and 99.5 ± 6.5% at 0.5 mg/mL). In conclusion, PCA/PLS-DA discriminated chemical variations by month, s*x, and bark type, but biomarkers showed overall stability and consistent anti-H. pylori activity, supporting phytotherapeutic standardization.

03/10/2026

🧬 Premio Langebio 2026 by Novogene | Convocatoria abierta

La Unidad de Genómica Avanzada del Cinvestav invita a personas recién graduadas de doctorado en México a participar en esta edición.

Podrán participar quienes hayan concluido su doctorado entre el 1 de agosto de 2025 y el 31 de julio de 2026, adscritos a una institución mexicana y cuyo trabajo de investigación haya sido desarrollado en México.

📅 Recepción de solicitudes hasta el 30 de octubre de 2026, a las 23:50 h (hora del centro de México).

Consulta las bases, requisitos y formato de solicitud en:
🔗 https://www.cinvestav.mx/uga-langebio/oferta-academica/convocatorias/premio-langebio-by-novogene-71

Centro de Investigación y de Estudios Avanzados

01/10/2026

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Background: Tityus championi is a species endemic to the southern Talamanca Mountain Range, along the border region between Costa Rica and Panama, and has been associated with severe clinical cases. Despite its medical relevance, the composition of its venom remains poorly studied. The present study aimed to characterize the proteomic composition of T. championi venom, identify its main toxin families, and recombinantly produce one of its most abundant and lethal toxins for potential use in antivenom development. Methods: Venom composition was analyzed by tandem mass spectrometry (MS/MS), enabling the identification of venom proteins. Subsequently, one of its primary lethal toxins (Tcham27) was identified and recombinantly expressed. Results: Proteomic analysis revealed that the most abundant family in the venom corresponded to metalloproteases, with 43 protein groups (17% of the total identifications), which are associated with processes such as hemorrhage, edema, inflammation, hypotension, and necrosis. CIIMET family toxins comprised 27 protein groups (11%). Among ion channel-acting toxins, 18 protein groups (7%) corresponded to sodium channel toxins and 14 (6%) to potassium channel toxins, homologous to components from geographically proximate species such as Tityus discrepans, Tityus cf. asthenes, and Tityus jaimei. Other relevant families included cysteine-rich secretory proteins (CRISPs; 6 proteins, 3%), serine proteases (5 proteins, 2%), and lectins (5 proteins, 2%). In addition, low-abundance components such as insulin-like growth factors, nucleotide pyrophosphatases, hyaluronidase, α-amylase, lipolysis-activated toxins, and chitinase were detected, contributing to the functional diversity of the venom. Conclusions: Proteomic characterization of T. championi venom demonstrates that metalloproteases constitute a major protein family alongside neurotoxins. Recombinant production of its most abundant toxic peptide, which is identical to toxins in the venom of geographically proximate Tityus species, provides a key tool for developing specific antivenoms.

28/09/2026

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Bougainvillea glabra Choisy (Nyctaginaceae) is a traditional medicinal plant and a source of betalains and phenolic compounds with potential antioxidant and cytotoxic properties that still remains underexplored. This study characterized a B. glabra extract (BGE) and evaluated its antioxidant capacity, cytotoxic effects, and modulation of intracellular ROS levels in Caco-2 cells. UPLC-MS identified 21 phenolic compounds, including rutin and quercetin, and two major betacyanins. BGE exhibited ABTS radical scavenging activity (156–188 µM TE), reduced intracellular ROS levels under basal and LPS-stimulated conditions, decreased Caco-2 cell viability, and enhanced the cytotoxic effect of cisplatin. These effects were associated with apoptosis- and autophagy-related markers, including p53 and Bcl-2 expression, and differential regulation of genes involved in caspase activation and NF-kB signaling. Overall, BGE exhibited antioxidant and cytotoxic activities, supporting its potential as a source of bioactive compounds for colorectal cancer research.

17/09/2026

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Background/Objectives: Hepatocellular carcinoma (HCC) is the most prevalent primary liver tumor and is often diagnosed at advanced stages with very poor therapeutic response, leading to high mortality. Thus, new therapeutic strategies and biomarkers are urgently needed. We previously showed that the combination of loratadine, raloxifene, and sorafenib exerts synergistic cytotoxicity on HCC cells. Here, we explored potential molecular mechanisms underlying the anticancer effects of this combination using multiomics analyses. Methods: We performed proteomic analyses based on mass spectrometry, transcriptomic analyses using the Clariom D Plus human microarray (Affymetrix), and metabolomic analyses based on nuclear magnetic resonance to investigate the profile changes induced by the drug combination in HuH7 cells. Bioinformatic analyses were applied to associate the omics changes with biological functions, molecular interactions, and clinical relevance in terms of patient survival. Results: We identified several molecules whose expression changed in response to treatment across the three omics profiles analyzed. Some of them were found to be involved in hallmarks of cancer, including sustained proliferation, evasion of growth suppressors, and resistance to cell death. Integrated multi-omics analyses revealed that the drug combination suppresses critical oncogenic drivers (C7orf50, NUP188, and HS2ST1) and that the mitotic cell cycle process, DNA synthesis and cholesterol biosynthesis are the primary pathways affected. Protein–protein interaction analysis revealed five key hubs (KIF2C, PCNA, TRIP13, NDC80, and RPA3), whose expression in HCC is associated with poor clinical prognosis. Conclusions: The combined treatment rewired molecular networks involved in HCC progression. These findings identify clinically relevant molecular targets associated with poor prognosis and provide mechanistic insights into the synergistic anticancer activity of this drug combination.

15/09/2026

🚨🚨🚨Atención🚨🚨🚨

EN
New deadline for registration and abstract submission! Register for the 10th SMP Symposium (https://www.smp.org.mx/xsymposium/). Your event registration includes one of the courses/workshops and society membership.

Register for the symposium at the following link:
https://docs.google.com/forms/d/e/1FAIpQLScoL9Y9KsAgM7PahaQ6gwOZL6TatSbga3pe6NEWw2mqvjvVyQ/viewform?pli=1

Choose your course or workshop using the following form:
https://docs.google.com/forms/d/e/1FAIpQLSfHh4QclOIa46rU2oAVRUp5NDEs0jG3COWOXT17A7ZVEOCvAA/viewform

ES
¡Nueva fecha límite para inscripción y envío de resúmenes! Regístrate al X Simposio de la SMP
(https://www.smp.org.mx/xsymposium/). Tu inscripción al evento incluye uno de los cursos/talleres y la membresía de pertenencia a la sociedad.

Inscríbete al simposio en el siguiente enlace:

https://docs.google.com/forms/d/e/1FAIpQLScoL9Y9KsAgM7PahaQ6gwOZL6TatSbga3pe6NEWw2mqvjvVyQ/viewform?pli=1

Escoge tu curso/taller en el siguiente formulario:
https://docs.google.com/forms/d/e/1FAIpQLSfHh4QclOIa46rU2oAVRUp5NDEs0jG3COWOXT17A7ZVEOCvAA/viewform

Dirección

Cuernavaca
62100

Página web

http://www.smp.org.mx/inicio

Notificaciones

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