28/07/2026
【植微研究成果— #吳亭穎】
🔶細胞分裂素的模組化演化：植物登陸過程中熱逆境與生長發育的整合
過去長期被視為主要調控生長發育的細胞分裂素（cytokinin）訊息傳遞路徑，現已證實為植物適應陸地環境的核心整合機制。比較基因體學與結構系統發生學分析指出，該磷酸中繼傳遞系統（phosphorelay）呈現階段性的組裝演化：在下游執行因子於演化過程中受到高度保守限制的同時，上游受體結構域則隨著不同演化支系對細胞分裂素使用偏好的改變而發生多樣化。具體而言，細胞分裂素的利用從早期分歧支系中富含順式玉米素（cis-zeatin）的系統，逐漸轉向維管束植物中以反式玉米素（trans-zeatin）為主的訊息傳遞模式。此外，在熱逆境條件下的跨支系轉錄體比較顯示，其生理輸出反應在演化過程中發生了網絡重整（rewiring）。儘管逆境下的生長抑制機制具有深度的演化保守性，但廣泛的代謝應答在不同支系間存在顯著差異：早期陸生植物傾向依賴與海藻糖相關的滲透保護作用（osmoprotection），而被子植物則轉型為基於氧化還原與物質運輸的應對策略。綜上所述，細胞分裂素訊息傳遞系統構成了一個模組化的演化框架，不僅在植物早期登陸時提供了環境適應的緩衝能力，隨後更透過機制演進，成功支撐了維管束植物複雜的形態建構。
➡️論文連結：https://www.sciencedirect.com/science/article/pii/S1360138526001688
➡️本所網頁：https://ipmb.sinica.edu.tw/ch/activities/highlights/556
【Publication Highlights—Ting-Ying Wu】
🔶Modular cytokinin evolution: Integrating heat stress and development during terrestrialization
Cytokinin signaling, long regarded primarily as a developmental regulator, has emerged as a central integrator of plant terrestrial adaptation. Comparative genomic and structural phylogenetics indicate a stepwise assembly of the phosphorelay, where receptor domains diversified alongside lineage-specific shifts in cytokinin usage, from cis-zeatin-enriched systems in early-diverging lineages toward trans-zeatin-dominant signaling in vascular plants, while downstream executors remained evolutionarily constrained. Cross-lineage transcriptomic comparisons under heat stress suggest a rewiring of physiological outputs. Although growth repression is deeply conserved, broader metabolic responses differ across clades: trehalose-associated osmoprotection in early land plants, whereas angiosperms transitioned to redox- and transport-based strategies. Overall, cytokinin signaling forms a modular framework that enabled early environmental buffering and was subsequently refined to support the complex architectures of vascular plants.
➡️Link: https://www.sciencedirect.com/science/article/pii/S1360138526001688
➡️IPMB website: https://ipmb.sinica.edu.tw/en/activities/highlights/556
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