Defense Advanced Research Projects Agency - DARPA

Defense Advanced Research Projects Agency - DARPA Official page of the U.S. Defense Advanced Research Projects Agency (DARPA)

www.darpa.mil DARPA's mission is to prevent and create strategic technological surprise by maintaining the technological superiority of the U.S.
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military. The Agency sponsors revolutionary, high-payoff research bridging the gap between fundamental discoveries and their military use.

Operating as usual

Funded in part by @NIH & the DARPA Safe Genes program, research from @MassGeneral published in @NatureBiotech demonstrat...
04/30/2021

Funded in part by @NIH & the DARPA Safe Genes program, research from @MassGeneral published in @NatureBiotech demonstrates the utility of CRISPR prime editing (PE) with purified ribonucleoprotein (RNP) complexes in zebrafish and primary human cells. These prime editors had previously been delivered using DNA or mRNA vectors only, and this research offers a broader therapeutic application of this platform and additional opportunities for creation of disease models in other vertebrates. https://www.nature.com/articles/s41587-021-00901-y

Funded in part by @NIH & the DARPA Safe Genes program, research from @MassGeneral published in @NatureBiotech demonstrates the utility of CRISPR prime editing (PE) with purified ribonucleoprotein (RNP) complexes in zebrafish and primary human cells. These prime editors had previously been delivered using DNA or mRNA vectors only, and this research offers a broader therapeutic application of this platform and additional opportunities for creation of disease models in other vertebrates. https://www.nature.com/articles/s41587-021-00901-y

Partially funded by the PReemptive Expression of Protective Alleles and Response Elements (PREPARE) program, researchers...
04/29/2021

Partially funded by the PReemptive Expression of Protective Alleles and Response Elements (PREPARE) program, researchers at @broadinstitute and colleagues have developed tissue atlases from autopsies conducted on deceased COVID patients. Pathology and cellular targets were published today in @Nature, and offer key insights into the biological impact of severe diseases and possible treatments. https://www.nature.com/articles/s41586-021-03570-8

Partially funded by the PReemptive Expression of Protective Alleles and Response Elements (PREPARE) program, researchers at @broadinstitute and colleagues have developed tissue atlases from autopsies conducted on deceased COVID patients. Pathology and cellular targets were published today in @Nature, and offer key insights into the biological impact of severe diseases and possible treatments. https://www.nature.com/articles/s41586-021-03570-8

In the 43rd episode of the Voices from DARPA podcast, Scott Wierzbanowski, a program manager since 2016 in the agency’s ...
04/26/2021

In the 43rd episode of the Voices from DARPA podcast, Scott Wierzbanowski, a program manager since 2016 in the agency’s Tactical Technology Office, recounts how he came of age in a family of test pilots and then embraced the mission of fostering technologies for amplifying the capabilities of airmen, their aircraft, and other defense assets in the sky. In this podcast, titled the “Sky Master,” Scott explains how the sky hasn’t even been the limit during his time at DARPA. https://www.darpa.mil/about-us/podcast

In the 43rd episode of the Voices from DARPA podcast, Scott Wierzbanowski, a program manager since 2016 in the agency’s Tactical Technology Office, recounts how he came of age in a family of test pilots and then embraced the mission of fostering technologies for amplifying the capabilities of airmen, their aircraft, and other defense assets in the sky. In this podcast, titled the “Sky Master,” Scott explains how the sky hasn’t even been the limit during his time at DARPA. https://www.darpa.mil/about-us/podcast

The software vulnerability disclosure process is fraught with challenges that put cybersecurity researchers and software...
04/23/2021

The software vulnerability disclosure process is fraught with challenges that put cybersecurity researchers and software makers at odds. DARPA’s SIEVE program is exploring potential solutions to this problem through the use of zero-knowledge proofs (ZKPs). One year into SIEVE, two research teams led by Galois and Trail of Bits have demonstrated that these mathematically verifiable problem statements could potentially be used by a vulnerability researcher (the prover) to convince a software maker (the verifier) that they possess information about a bug or exploit without revealing sensitive details – like how the vulnerability was uncovered.
#cybersecurity #software #zeroknowledge

The software vulnerability disclosure process is fraught with challenges that put cybersecurity researchers and software makers at odds. DARPA’s SIEVE program is exploring potential solutions to this problem through the use of zero-knowledge proofs (ZKPs). One year into SIEVE, two research teams led by Galois and Trail of Bits have demonstrated that these mathematically verifiable problem statements could potentially be used by a vulnerability researcher (the prover) to convince a software maker (the verifier) that they possess information about a bug or exploit without revealing sensitive details – like how the vulnerability was uncovered.
#cybersecurity #software #zeroknowledge

DYK DARPA offers Small Business Innovation Research (SBIR) & Small Business Technology Transfer (STTR) grants? These pro...
04/20/2021

DYK DARPA offers Small Business Innovation Research (SBIR) & Small Business Technology Transfer (STTR) grants? These programs are highly competitive, and encourage domestic small businesses to engage in Federal Research/Research and Development (R/R&D) with the potential for commercialization.

One recent recipient, SecondWave Systems, is conducting first-in human clinical trials using ultrasound stimulation to address hyperinflammation in severe cases of COVID-19. Learn more at how to work with us at: https://www.darpa.mil/work-with-us/for-small-businesses/participate-sbir-sttr-program

DYK DARPA offers Small Business Innovation Research (SBIR) & Small Business Technology Transfer (STTR) grants? These programs are highly competitive, and encourage domestic small businesses to engage in Federal Research/Research and Development (R/R&D) with the potential for commercialization.

One recent recipient, SecondWave Systems, is conducting first-in human clinical trials using ultrasound stimulation to address hyperinflammation in severe cases of COVID-19. Learn more at how to work with us at: https://www.darpa.mil/work-with-us/for-small-businesses/participate-sbir-sttr-program

Chemical and biological (CB) threats have become increasingly ubiquitous and diverse, presenting significant risks to wa...
04/19/2021

Chemical and biological (CB) threats have become increasingly ubiquitous and diverse, presenting significant risks to warfighters in theater and stability operators during pandemic outbreaks. State-of-the-art personal protective equipment (PPE) can be bulky, heavy, and cumbersome, often severely limiting user mobility and performance. The Personalized Protective Biosystem (PPB) program aims to develop technology that reduces the need for burdensome protective equipment while increasing individual protection against CB threats.

DARPA recently awarded contracts to the following performers, FLIR Systems, Leidos, and Charles River Analytics, to develop lightweight materials and adaptable, tissue-protective countermeasures to provide on-demand, broad spectrum, and rapid long-term protection. Performers will seek to leverage molecular technologies and commensal organisms to unburden protective equipment demands from the user.
https://www.darpa.mil/news-events/2021-04-19

Chemical and biological (CB) threats have become increasingly ubiquitous and diverse, presenting significant risks to warfighters in theater and stability operators during pandemic outbreaks. State-of-the-art personal protective equipment (PPE) can be bulky, heavy, and cumbersome, often severely limiting user mobility and performance. The Personalized Protective Biosystem (PPB) program aims to develop technology that reduces the need for burdensome protective equipment while increasing individual protection against CB threats.

DARPA recently awarded contracts to the following performers, FLIR Systems, Leidos, and Charles River Analytics, to develop lightweight materials and adaptable, tissue-protective countermeasures to provide on-demand, broad spectrum, and rapid long-term protection. Performers will seek to leverage molecular technologies and commensal organisms to unburden protective equipment demands from the user.
https://www.darpa.mil/news-events/2021-04-19

As part of the DARPA INTERfering and Co-Evolving Prevention and Therapy (INTERCEPT) program, Institut Pasteur researcher...
04/18/2021

As part of the DARPA INTERfering and Co-Evolving Prevention and Therapy (INTERCEPT) program, Institut Pasteur researchers and colleagues have recently identified defective viral genome sequences that can be used as therapeutic interfering particles against Zika virus infection and show antiviral activity in mosquitoes and mice. The program aims to harness viral evolution to create a novel, adaptive form of medical countermeasure—therapeutic interfering particles (TIPs)—that outcompetes viruses in the body to prevent or treat infection. Learn more in Nature Communication: https://www.nature.com/articles/s41467-021-22341-7]

As part of the DARPA INTERfering and Co-Evolving Prevention and Therapy (INTERCEPT) program, Institut Pasteur researchers and colleagues have recently identified defective viral genome sequences that can be used as therapeutic interfering particles against Zika virus infection and show antiviral activity in mosquitoes and mice. The program aims to harness viral evolution to create a novel, adaptive form of medical countermeasure—therapeutic interfering particles (TIPs)—that outcompetes viruses in the body to prevent or treat infection. Learn more in Nature Communication: https://www.nature.com/articles/s41467-021-22341-7]

As part of the DARPA Living Foundries program, researchers at North Dakota State University and Zymergen successfully de...
04/18/2021

As part of the DARPA Living Foundries program, researchers at North Dakota State University and Zymergen successfully demonstrated their high-throughput approach to carry out polyesterification reactions. Published in the Journal of Polymer Science, their method offers highly controllable and reproducible reaction conditions in every reactor coupled with the ability to use a minimum amount of reagents.

DARPA’s Living Foundries program aims to enable adaptable, scalable, and on-demand production of such molecules by programming the fundamental metabolic processes of biological systems to generate a vast number of complex molecules that are not otherwise accessible: https://onlinelibrary.wiley.com/doi/10.1002/pol.20210059

As part of the DARPA Living Foundries program, researchers at North Dakota State University and Zymergen successfully demonstrated their high-throughput approach to carry out polyesterification reactions. Published in the Journal of Polymer Science, their method offers highly controllable and reproducible reaction conditions in every reactor coupled with the ability to use a minimum amount of reagents.

DARPA’s Living Foundries program aims to enable adaptable, scalable, and on-demand production of such molecules by programming the fundamental metabolic processes of biological systems to generate a vast number of complex molecules that are not otherwise accessible: https://onlinelibrary.wiley.com/doi/10.1002/pol.20210059

Had COVID and think you don’t need a vaccine? Think again. Data published in Lancet Respiratory Medicine by ECHO perform...
04/16/2021

Had COVID and think you don’t need a vaccine? Think again. Data published in Lancet Respiratory Medicine by ECHO performers at the Icahn School of Medicine at Mount Sinai and colleagues demonstrate that past COVID-19 infection doesn’t fully protect young people against reinfection.

The study found that participants who had not previously been infected with SARS-CoV-2 (seronegative) had a five times greater risk of infection than participants who were previously infected (seropositive), but seropositive people are still at risk of reinfection.
https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(21)00158-2/fulltext

Had COVID and think you don’t need a vaccine? Think again. Data published in Lancet Respiratory Medicine by ECHO performers at the Icahn School of Medicine at Mount Sinai and colleagues demonstrate that past COVID-19 infection doesn’t fully protect young people against reinfection.

The study found that participants who had not previously been infected with SARS-CoV-2 (seronegative) had a five times greater risk of infection than participants who were previously infected (seropositive), but seropositive people are still at risk of reinfection.
https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(21)00158-2/fulltext

A Proposers Day for our recently announced Quantum Benchmarking program is scheduled for April 20 via webcast. Potential...
04/13/2021

A Proposers Day for our recently announced Quantum Benchmarking program is scheduled for April 20 via webcast. Potential proposers may find more information and registration details here: https://go.usa.gov/xHgtg

A Proposers Day for our recently announced Quantum Benchmarking program is scheduled for April 20 via webcast. Potential proposers may find more information and registration details here: https://go.usa.gov/xHgtg

Our new TRIAD AI Exploration program seeks to create a streamlined processing approach by applying machine-learning insp...
04/09/2021

Our new TRIAD AI Exploration program seeks to create a streamlined processing approach by applying machine-learning inspired algorithms directly to a phased array aperture to cut down on processing time and cost. Deadline for submissions is 30 April: https://go.usa.gov/xHrE9

Our new TRIAD AI Exploration program seeks to create a streamlined processing approach by applying machine-learning inspired algorithms directly to a phased array aperture to cut down on processing time and cost. Deadline for submissions is 30 April: https://go.usa.gov/xHrE9

Our new Low Temperature Logic Technology (LTLT) program aims to develop high-performance, very low temperature (~77K or ...
04/08/2021

Our new Low Temperature Logic Technology (LTLT) program aims to develop high-performance, very low temperature (~77K or -321F) electronic device technology that is capable of achieving a 25X improvement in performance/power compared to state-of-the-art central CPUs operating at room temperature. These advances could help overcome the barriers to thermal and power density scaling in high performance computing systems we face today. Accepting proposals until 5/18: https://www.darpa.mil/news-events/2021-04-08

Our new Low Temperature Logic Technology (LTLT) program aims to develop high-performance, very low temperature (~77K or -321F) electronic device technology that is capable of achieving a 25X improvement in performance/power compared to state-of-the-art central CPUs operating at room temperature. These advances could help overcome the barriers to thermal and power density scaling in high performance computing systems we face today. Accepting proposals until 5/18: https://www.darpa.mil/news-events/2021-04-08

P3 performer AbCellera has demonstrated efficacy of their antibody, bamlanivimab (LY-CoV555), as both a prophylactic aga...
04/06/2021

P3 performer AbCellera has demonstrated efficacy of their antibody, bamlanivimab (LY-CoV555), as both a prophylactic against – and therapy for – COVID-19. New results in Science Translational Medicine showed decreased SARS-CoV-2 viral shedding & transmission by blocking virus replication in the upper airway. Researchers found that bamlanivimab has greater affinity and potency relative to other RBD-binding and ACE2-blocking antibodies tested in the study, and could provide protection against viral variants when administered with another antibody. https://stm.sciencemag.org/content/early/2021/04/05/scitranslmed.abf1906]

P3 performer AbCellera has demonstrated efficacy of their antibody, bamlanivimab (LY-CoV555), as both a prophylactic against – and therapy for – COVID-19. New results in Science Translational Medicine showed decreased SARS-CoV-2 viral shedding & transmission by blocking virus replication in the upper airway. Researchers found that bamlanivimab has greater affinity and potency relative to other RBD-binding and ACE2-blocking antibodies tested in the study, and could provide protection against viral variants when administered with another antibody. https://stm.sciencemag.org/content/early/2021/04/05/scitranslmed.abf1906]

In this episode of the Voices from DARPA podcast, Whitney Mason, a program manager since 2017 in the agency’s Microsyste...
04/05/2021

In this episode of the Voices from DARPA podcast, Whitney Mason, a program manager since 2017 in the agency’s Microsystems Technology Office, explains how she became smitten with the science and technology of imaging. Even as a child, Mason was curious about the world, wondering about everything, she says, from why the sky is blue to what makes concrete hard. But what ended up inspiring her most and cementing in her professional trajectory was the fantastic ways that animals see, including the ability to see in the night using infrared light. “A soldier needs to see at night,” Mason says. “Or see through dust. Or find homemade explosives. Or find things really far away. Or track things.” That list of warfighters’ sensory needs explains a lot about the bold portfolio of projects Mason oversees at DARPA. https://www.darpa.mil/about-us/podcast

In this episode of the Voices from DARPA podcast, Whitney Mason, a program manager since 2017 in the agency’s Microsystems Technology Office, explains how she became smitten with the science and technology of imaging. Even as a child, Mason was curious about the world, wondering about everything, she says, from why the sky is blue to what makes concrete hard. But what ended up inspiring her most and cementing in her professional trajectory was the fantastic ways that animals see, including the ability to see in the night using infrared light. “A soldier needs to see at night,” Mason says. “Or see through dust. Or find homemade explosives. Or find things really far away. Or track things.” That list of warfighters’ sensory needs explains a lot about the bold portfolio of projects Mason oversees at DARPA. https://www.darpa.mil/about-us/podcast

How will we know how revolutionary universal, fault-tolerant quantum computers will really be? DARPA's Quantum Benchmark...
04/02/2021

How will we know how revolutionary universal, fault-tolerant quantum computers will really be? DARPA's Quantum Benchmarking program aims to find out. Its goal is to develop “yardsticks” for measuring the value of future quantum information systems: https://www.darpa.mil/news-events/2021-04-02

How will we know how revolutionary universal, fault-tolerant quantum computers will really be? DARPA's Quantum Benchmarking program aims to find out. Its goal is to develop “yardsticks” for measuring the value of future quantum information systems: https://www.darpa.mil/news-events/2021-04-02

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