05/11/2026
Researchers engineered protein-like polymers that replicate complex enzyme functions. This work, which was verified using X-ray characterization techniques at the Advanced Light Source (ALS), offers a cost-effective, scalable approach that paves the way for functional materials in biomedicine, energy, and manufacturing. Read more: https://als.lbl.gov/a-new-framework-for-designing-synthetic-enzymes/
📸 Schematic comparing the global folding patterns, chemical structures, and active sites of a) natural protein demonstrating a rigid secondary structure of regular, local folding patterns in the chain of amino acids; and b) the protein-like polymers created in this study, which do not form secondary structures but instead adopt varying conformations based on the hydrophobic (water-repelling) properties of segments in the chain. Red, grey, blue and yellow correspond to very hydrophobic, hydrophobic, hydrophilic (water-loving) and very hydrophilic amino acid residues, respectively. The chemical structures of key functional residues are shown in the inset boxes. (Credit: Ting Xu/UC Berkeley/LBNL)