The Dog Genome Project, under the expert guidance of Dr. Elaine Ostrander, has a long history in the field of canine genetic research. Because the selection for these traits has been both recent and strong, modern breeds are an excellent system in which to find genetic variants responsible for major morphological features. The closed-breed structure of the domestic dog also serves well to investig
ate genetic predilections for breed-specific diseases and cancer. The Ostrander lab developed the first marker set for genetic mapping in dogs and, in 1997, constructed the first canine meiotic linkage map. Together with collaborators, we have published successful contributions to the areas of canine kidney cancer, epilepsy, osteoarthritis, Addison's disease, somatic cell carcinomas, retinopathies, and venereal tumors. We've made strides in canine morphological research as well, specifically in terms of body size, hair type and color, and skull shape. Current research projects encompass canine bladder cancer, histiocytic sarcoma, gastric cancer, skull shape and dentition, breed population genetics and phylogeny, and selection of behavior and domestication. The NHGRI Dog Genome Project is driven by citizen science and involves the participation of thousands of enthusiastic dog owners. All DNA samples are collected from pet dogs and voluntarily submitted by owners and veterinarians. We do not house, breed, or conduct experiments on dogs.
