California Institute for Regenerative Medicine

California Institute for Regenerative Medicine The California Institute for Regenerative Medicine, California's Cell & Gene Therapy Agency CIRM is California's Stem Cell Agency.
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Our mission is to accelerate world class science to deliver transformative regenerative medicine treatments in an equitable manner to a diverse California and world.

Among the awards is a $12.4 million grant to support a Phase 2b clinical trial to evaluate the safety and efficacy of a ...
07/27/2023

Among the awards is a $12.4 million grant to support a Phase 2b clinical trial to evaluate the safety and efficacy of a stem cell-based retinal implant in patients with geographic atrophy, a late-stage form of age-related macular degeneration (AMD), a common condition that can lead to vision loss in older adults.

The California Institute for Regenerative Medicine (CIRM), the world’s largest institution dedicated to regenerative medicine, today awarded $50.1 million to fund clinical-stage research projects a…

Thanks to $17 million in early funding from the California Institute for Regenerative Medicine (CIRM) and the unwavering...
06/28/2023

Thanks to $17 million in early funding from the California Institute for Regenerative Medicine (CIRM) and the unwavering dedication of researchers like Dr. Stephanie Cherqui at UC San Diego, a gene therapy to address cystinosis is making its way through the field.

Learn more: https://bit.ly/3NtfURb

05/16/2023

The California Institute for Regenerative Medicine is a proud partner of the Foundation for the National Institutes of Health through the Accelerating Medicines Partnership® Bespoke Gene Therapy Consortium (AMP BGTC).

We're demonstrating our commitment by funding gene therapy research for Congenital Hereditary Endothelial Dystrophy (CHED), a corneal condition affecting children.

Five-year-old Seersha Sulack will become only the second child in the US in the past five years to receive a life-saving...
04/27/2023

Five-year-old Seersha Sulack will become only the second child in the US in the past five years to receive a life-saving gene therapy treatment for her thanks to a partnership between California Institute for Regenerative Medicine, a group of persistent parents at SCID, Angels for Life Foundation and researchers at the Broad Stem Cell Research Center at UCLA.

Later this spring, a little girl in California who essentially has no immune system will receive a lifesaving treatment for "bubble boy disease" thanks to the persistence of a dogged group of parents, a pediatrician, a veteran newsman and a few episodes of "Grey's Anatomy."

"It is critical that the stakeholders, Parkinson's Disease patients and California citizens understand the impact that n...
04/25/2023

"It is critical that the stakeholders, Parkinson's Disease patients and California citizens understand the impact that new treatments and even a cure could have."

April is Parkinson’s Awareness Month and the California Institute for Regenerative Medicine (CIRM) is joining the campaign to —take 6 minutes to raise Parkinson’s awareness and highlight…

To date, the California Institute for Regenerative Medicine (CIRM) has invested more than $60 million in helping regener...
04/19/2023

To date, the California Institute for Regenerative Medicine (CIRM) has invested more than $60 million in helping regenerative medicine research for Parkinson's progress from a discovery level through clinical trials.

April is Parkinson’s Awareness Month and the California Institute for Regenerative Medicine (CIRM) is joining the campaign to —take 6 minutes to raise Parkinson’s awareness and highlight…

“This is a common injury, and as our population ages, there’s a pressing need to find new solutions," said Dr. Darryl D’...
04/10/2023

“This is a common injury, and as our population ages, there’s a pressing need to find new solutions," said Dr. Darryl D’Lima, director of orthopedic research at Scripps Research and the initiative’s lead investigator.

The California Institute for Regenerative Medicine (CIRM) has awarded a $2.7 million research grant to Scripps Health to investigate the use of stem cells to engineer rotator cuff tendons in the la…

CIRM bids farewell and expresses its deepest gratitude to Sen. Art Torres (ret) and Jonathan Thomas ("JT") for their ser...
03/29/2023

CIRM bids farewell and expresses its deepest gratitude to Sen. Art Torres (ret) and Jonathan Thomas ("JT") for their service on our Board and their dedication to the advancement of stem cell research in California.

Under a new law, clinical trial sponsors will be required to submit a diversity action plan to the FDA along with other ...
03/20/2023

Under a new law, clinical trial sponsors will be required to submit a diversity action plan to the FDA along with other important trial documents.

The California Institute for Regenerative Medicine (CIRM) is proud to join fellow advocates of clinical trial diversity in applauding a new law that will allow the U.S. Food & Drug Administrati…

February 28th is Rare Disease Day. It’s a day to remind ourselves of the millions of people, and their families, struggl...
02/28/2023

February 28th is Rare Disease Day. It’s a day to remind ourselves of the millions of people, and their families, struggling with these diseases.

Here at the California Institute for Regenerative Medicine, we understand the importance of funding research that impacts not just the most common diseases.

In fact, 50% of all the projects we fund target a rare disease or condition such as: Retinitis pigmentosa, Sickle cell disease, Huntington’s disease, and Duchenne Muscular Dystrophy.

Tomorrow, February 28th, is Rare Disease Day. It’s a day to remind ourselves of the millions of people, and their families, struggling with these diseases. These conditions are also called orphan d…

Recent news of the 53-year-old man in Germany who was declared free of HIV after receiving a stem cell transplant shows ...
02/23/2023

Recent news of the 53-year-old man in Germany who was declared free of HIV after receiving a stem cell transplant shows the importance of continued research.

At the California Institute for Regenerative Medicine (CIRM), we have invested more than $85 million in the search for stem cell and gene therapy treatments for HIV/AIDS, ranging from basic Discovery research to clinical trials.

A recent article in Nature shared the news about a 53-year-old man in Germany who was declared free of HIV after receiving virus-resistant cells. The man—referred to as the “Düsseldorf patient”—wa…

A man with HIV is now virus-free after receiving a stem cell transplant, making him one of only a handful of people to b...
02/22/2023

A man with HIV is now virus-free after receiving a stem cell transplant, making him one of only a handful of people to be considered cured after the treatment.

The 53-year-old known as the "Düsseldorf Patient" also had cancer and received a bone marrow transplant which replaced his cells with a donor's HIV-resistant stem cells.

Dr. Vito Imbasciani will be the new Chair of the California Institute for Regenerative Medicine (CIRM), the state agency...
01/27/2023

Dr. Vito Imbasciani will be the new Chair of the California Institute for Regenerative Medicine (CIRM), the state agency created by voters in 2004 and funded again in 2020 to invest in stem cell and regenerative medicine research and treatments.

Dr. Vito Imbasciani will be the new Chair of the California Institute for Regenerative Medicine (CIRM), the state agency created by voters in 2004 and funded again in 2020 to invest in stem cell an…

The California Institute for Regenerative Medicine has awarded a grant to Dr. Natalia Gomez-Ospina and her team at Stanf...
01/23/2023

The California Institute for Regenerative Medicine has awarded a grant to Dr. Natalia Gomez-Ospina and her team at Stanford for a late-stage preclinical program for .

Children with the syndrome lack an enzyme the body needs to digest sugar and experience progressive brain, heart, organ damage. There is no effective treatment and life expectancy for many of these children is only around 10 years.

The California Institute for Regenerative Medicine (CIRM) awarded $5,444,353 to Dr. Natalia Gomez-Ospina and her team at Stanford University for a late-stage preclinical program targeting Severe Mu…

When HT was born in a remote part of the Navajo nation, he was quickly diagnosed with a rare and usually fatal condition...
01/11/2023

When HT was born in a remote part of the Navajo nation, he was quickly diagnosed with a rare and usually fatal condition.

Today, thanks to a therapy developed at UCSF and funded by the California Institute for Regenerative Medicine, he’s a healthy four-year-old boy running around in cowboy boots.

Photo credit: UCSF Hataalii Tiisyatonii Begay (HT) is paving the road for newborns with SCID. When HT was born in 2018 in a remote part of the Navajo nation, he was quickly diagnosed with a rare an…

When HT was born in 2018 in a remote part of the Navajo nation, he was quickly diagnosed with a rare and -usually fatal-...
01/11/2023

When HT was born in 2018 in a remote part of the Navajo nation, he was quickly diagnosed with a rare and -usually fatal- condition.

Today, thanks to a therapy developed at UCSF and funded by CIRM, he’s a healthy four-year-old boy running around in cowboy boots.

Photo credit: UCSF Hataalii Tiisyatonii Begay (HT) is paving the road for newborns with SCID. When HT was born in 2018 in a remote part of the Navajo nation, he was quickly diagnosed with a rare an…

ICYMI
12/28/2022

ICYMI

This year was a momentous one for the California Institute for Regenerative Medicine (CIRM). You can read some of our achievements in our 2021-2022 annual report. As always, we shared our most ex…

On behalf of the team at the California Institute for Regenerative Medicine, we wish you a safe and happy holiday!Thank ...
12/22/2022

On behalf of the team at the California Institute for Regenerative Medicine, we wish you a safe and happy holiday!

Thank you to the people of California and our wonderful community for making 2022 a successful year.

“If successful, this approach can overcome hurdles to the success of chemotherapy and blood stem cell transplantation fo...
12/20/2022

“If successful, this approach can overcome hurdles to the success of chemotherapy and blood stem cell transplantation for the treatment of advanced blood cancer,” says Dr. Maria T. Millan, President and CEO of CIRM.

Blood stem cell transplantation following high dose chemotherapy is standard of care and potentially curative for aggressive forms of lymphoma. However, this treatment regimen is limited by severe …

CIRM lost its voice this weekend.   Sunday evening, our beloved Director of Patient Advocacy and frequent face and voice...
12/16/2022

CIRM lost its voice this weekend.

Sunday evening, our beloved Director of Patient Advocacy and frequent face and voice of the Institute, Kevin McCormack, passed away unexpectedly, leaving an unfillable void in our hearts.

CIRM lost its voice this weekend.    Sunday evening, our beloved Director of Patient Advocacy and frequent face and voice of the Institute, Kevin McCormack, passed away unexpectedly,…

During the CIRM SPARK summer internship, the high school student joined a lab at Sanford Burnham Prebys to study Duchenn...
12/07/2022

During the CIRM SPARK summer internship, the high school student joined a lab at Sanford Burnham Prebys to study Duchenne Muscular Dystrophy (DMD) and how stem cells can be used to provide treatment.

Earlier this year, CIRM welcomed many energetic and enthusiastic high school students at the 2022 SPARK Program annual conference in Oakland. The SPARK program is one of the California Institute fo…

El bebé Tobi recibió un tratamiento de células madre, financiado por el CIRM, mientras aún estaba en el útero. “Cuando l...
12/01/2022

El bebé Tobi recibió un tratamiento de células madre, financiado por el CIRM, mientras aún estaba en el útero.

“Cuando lo abrazamos por primera vez dijimos, ‘No puedo creer que hayamos hecho esto. Lo logramos. Lo hicimos sin saber si funcionaría’.”

El bebé, Tobi, que recibió un tratamiento de células madre financiado por el CIRM, mientras aún estaba en el útero, y sus padres Michelle y Jeff. To read this blog in English, click here. Michelle …

Both patients entered the study with a history of significant monthly seizures that were not controlled by anti-seizure ...
11/30/2022

Both patients entered the study with a history of significant monthly seizures that were not controlled by anti-seizure medications.

So far, they have both seen encouraging signs of reduced seizures which suggest that a single dose of NRTX-1001 may have a long-lasting ability to suppress seizures.

Nearly 3.5 million Americans suffer from some form of epilepsy. It can affect people in different ways from stiff muscles or staring spells, to violent shaking and loss of consciousness. …

🎶 When the working day is done oh nerds just wanna have funds. 🎶
11/23/2022

🎶 When the working day is done oh nerds just wanna have funds. 🎶

We at the California Institute for Regenerative Medicine have a lot to be thankful for this Thanksgiving. We get to work with some extraordinary colleagues, we get to know some remarkable patient a…

Caring Cross announced recently that they have dosed the first patient in the trial testing their anti-HIV duoCAR-T cell...
11/21/2022

Caring Cross announced recently that they have dosed the first patient in the trial testing their anti-HIV duoCAR-T cell therapy.

The goal of this one-time therapy is to act as a long-term control of HIV with patients no longer needing to take anti-HIV medications. If it is successful it would be, in effect, a form of functional HIV cure.

Dr. Steven Deeks. Photo courtesy UCSF I’ve always been impressed by the willingness of individuals to step forward and volunteer for a clinical trial. Even more so when they are the first person ev…

“We are hopeful that it might one day be possible to inject an antibody at specific sites in the body to regenerate musc...
11/18/2022

“We are hopeful that it might one day be possible to inject an antibody at specific sites in the body to regenerate muscle in older people or to counteract functional problems due to disease or surgery.”

A study by Stanford Medicine researchers in older mice may lead to treatments that help seniors regain muscle strength lost to aging. Muscle stem cells—which are activated in response to muscle inj…

There’s more encouraging news from a CIRM-funded clinical trial for severe combined immunodeficiency (SCID) with Jasper ...
11/14/2022

There’s more encouraging news from a CIRM-funded clinical trial for severe combined immunodeficiency (SCID) with Jasper Therapeutics.

They have announced that they have tested their approach in 16 patients, with encouraging results and no serious adverse events.

Dr. Judy Shizuru: Photo courtesy Jasper Therapeutics Over the years the California Institute for Regenerative Medicine (CIRM) has invested a lot in helping children born with severe combined immuno…

The California Institute for Regenerative Medicine (CIRM) has been named as a finalist for the Patient Advocacy Award (n...
11/08/2022

The California Institute for Regenerative Medicine (CIRM) has been named as a finalist for the Patient Advocacy Award (non-profit category) as part of the Phacilitate Advanced Therapies Awards.

It’s always nice to be told you are doing a good job. It’s even nicer when it’s unexpected. That’s certainly the case when we, the Communications Team at the California Institute for Regenerative M…

Dr. Dennis Clegg has lots of titles and honors but what makes him most interesting is the progress he is helping drive i...
11/02/2022

Dr. Dennis Clegg has lots of titles and honors but what makes him most interesting is the progress he is helping drive in finding cures for macular degeneration, one of the leading causes of vision loss in the world.

In this podcast Dennis talks about how a small patch they have developed is showing real promise in restoring vision.

Dennis Clegg, UC Santa Barbara researcher Doctor Dennis Clegg, a researcher and scientist at UC Santa Barbara, is fascinated by the eye. He thinks it’s one of the most beautiful objects in na…

Dr. Lili Yang is working on developing a stem cell-derived Natural Killer cell that can attack cancer. She is doing it i...
10/27/2022

Dr. Lili Yang is working on developing a stem cell-derived Natural Killer cell that can attack cancer.

She is doing it in a way that she hopes will make the therapy more effective, cheaper and widely available to everyone who needs it.

Lili Yang UCLA Broad Stem Cell Research Center: Photo courtesy Reed Hutchinson PhotoGraphics When Lili Yang was studying for her PhD she approached her mentor, the Nobel Laureate Dr. David Baltimor…

Congratulations to Senator Art Torres (Ret.), the Vice Chair of the CIRM Board, who received a Dolores Huerta Lifetime A...
10/25/2022

Congratulations to Senator Art Torres (Ret.), the Vice Chair of the CIRM Board, who received a Dolores Huerta Lifetime Achievement Award this month!

During the ceremony, Dolores Huerta sent a video greeting from Texas (where she lives) and San Francisco Mayor London Breed presented him with a Certificate of Honor.

Mayor Breed praised Art for supporting immigrant communities, uplifting Latino residents, and for his advocacy and passion to secure critical funding for stem cell research in California.

We are thrilled to have Senator Art Torres (Ret.) serve on our Board and congratulate him for this amazing achievement!

Read more: https://bit.ly/3TUUbDv

To date, no vaccines or other treatments have been approved for Zika virus.
10/17/2022

To date, no vaccines or other treatments have been approved for Zika virus.

Zika is caused by a virus that is mainly transmitted by infected female Aedes aegypti mosquitoes but also through sexual in*******se. People infected by Zika virus usually have mild symptoms that n…

More promising news from the CIRM-funded stem cell clinical trial at UC Davis Health treating spina bifida. The three ba...
10/14/2022

More promising news from the CIRM-funded stem cell clinical trial at UC Davis Health treating spina bifida.

The three babies from the trial that have been born so far will be monitored by the research team until 30 months of age to fully assess the procedure’s safety and effectiveness.

He was diagnosed with spina bifida while still in the womb, but thanks to this procedure he was born happy and healthy.

CIRM’s goal is that the outcomes of the projects derived from this opportunity will ultimately create new avenues and pr...
10/13/2022

CIRM’s goal is that the outcomes of the projects derived from this opportunity will ultimately create new avenues and provide a rigorous foundation for translational and clinical development work.

The California Institute for Regenerative Medicine (CIRM) is pleased to announce a new opportunity within our current funding cycle for Discovery stage programs: the DISC0 …

The first phase of the clinical trial is funded by a $9 million state grant from the California Institute for Regenerati...
10/07/2022

The first phase of the clinical trial is funded by a $9 million state grant from the California Institute for Regenerative Medicine (CIRM).

Three babies have been born after receiving the world’s first spina bifida treatment combining surgery with stem cells. This was made possible by a landmark clinical trial at UC Davis Health known formally as the “CuRe Trial: Cellular Therapy for In Utero Repair of Myelomeningocele.” 

CIRM congratulates Carolyn Bertozzi for winning the Nobel Prize in Chemistry! Bertozzi helped jump-start human embryonic...
10/06/2022

CIRM congratulates Carolyn Bertozzi for winning the Nobel Prize in Chemistry!

Bertozzi helped jump-start human embryonic stem cell (hESC) research in California and had a hand in early CIRM-funded stem cell research.

Carolyn Bertozzi. Image credit: Andrew Brodhead The 2022 Nobel Prize in Chemistry has been awarded to Carolyn R. Bertozzi of Stanford University, Morten Meldal of the University of Copenhagen, and …

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Researchers are developing off-the-shelf treatments to save joints before they wear out. They have demonstrated its efficacy in animal models. Translation of this treatment into the clinics is currently underway with a $6 million grant from the California Institute for Regenerative Medicine.

A new California Institute for Regenerative Medicine blog post tells the story of Jake Javier, a patient who received $LCTX’s OPC1 therapy in a clinical trial.

Read: https://bit.ly/3WeRPR7

Patient Spotlight Part 2 – In 2016, Jake Javier was paralyzed from the neck down. In late 2022, he is set to graduate with his master’s degree from Duke University.

Hear his story: https://bit.ly/3uxYLNg

California Institute for Regenerative Medicine $LCTX
Patient Spotlight – In 2016, Jake Javier was paralyzed from the neck down. In late 2022, he is set to graduate with his master’s degree from Duke University.

Hear his story: https://bit.ly/3FtVMfc

California Institute for Regenerative Medicine $LCTX
As if this week wasn't already amazing enough with all of your incredible support on Giving Tuesday, we just received the momentous news that the California Institute for Regenerative Medicine has awarded a $4 million dollar grant to Mahzi Therapeutics to accelerate their work in Pitt Hopkins Gene Therapy based on the work you all funded! We couldn't be more grateful to Mahzi, CIRM and all of you. This is BIG!

Read more about it here:
https://www.cirm.ca.gov/our-progress/awards/development-gene-therapy-treatment-pitt-hopkins-syndrome-phs-translating-animal

Mahzi, a rare disease therapeutic company started by esteemed scientists from the successful biotech, Ultragenyx, launched earlier this year with Pitt Hopkins as one of their first 3 pipeline indications. We were honored they chose us, and are even more honored and grateful that they saw so much promise in the work of Drs. Alysson Muotri and Fabio Papes (PTHS Uncle) at UCSD that they applied for this grant. For the CIRM to also see the promise and make this unprecedented investment into Pitt Hopkins translational work is absolutely transformative for our community! We are hopeful to see this therapy launch in human clinical trials in 2024.

To those of you who have donated, THANK YOU, FOR MAKING DREAMS A REALITY!
Our expanded stem-cell research programs will prepare more students to explore and advance in scientific careers in regenerative medicine, a field focused on developing stem cell treatments to heal or replace tissues and organs damaged by aging, disease and defects. Huge thanks to the California Institute for Regenerative Medicine, for the support!
To advance approved treatments that will be available to Californians from all backgrounds, the USC+CHLA Alpha Clinic will use a new $8M grant from California Institute for Regenerative Medicine (CIRM) to expand personnel dedicated to advancing clinical trials of new cell and gene therapies, engage underserved communities in such studies, and train the workforce that conducts them.

“These cell- and gene-based strategies take advantage of really complex machinery that Mother Nature has developed over a billion and a half years of evolution,” said Tom Buchanan, MD, program director of the USC+CHLA Alpha Clinic and vice dean of research of the Keck School of Medicine of USC. “They could change the way we practice medicine.”

USC Stem Cell
Children's Hospital Los Angeles
USC Norris Comprehensive Cancer Center at Keck Medicine of USC
This image might look like a celestial view through a telescope, but what you’re actually seeing is a microscopic picture of a colony of stem cells (light blue) growing on fibroblasts (dark blue) captured by researchers at California Institute for Regenerative Medicine https://bit.ly/3VNHv36
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I Peace, Inc., partners with the California Institute for Regenerative Medicine (CIRM) - https://bioinformant.com/i-peace-partners-with-cirm/

I Peace, Inc. announced the company has agreed to join the California Institute for Regenerative Medicine’s (CIRM) Industry Resource Partner Program to pave way for the provision of Good Manufacturing Practice (GMP) iPSCs for various research programs funded by CIRM.

I Peace has been providing GMP Induced Pluripotent Stem Cells (iPSC) for a variety of cell therapy developers and pharmaceutical companies in the past several years and we believe this wonderful partnership with CIRM reflects the high-quality of our cell products and accompanying services.

I Peace is providing access to excellent quality, well-characterized iPSC lines via I Peace’s proprietary technologies and profound iPSC expertise, I Peace is offering research-grade iPSCs derived from GMP iPSCs to CIRM’s Discovery pursuit stage research projects for product development in regenerative medicine.

Read more at: https://bioinformant.com/i-peace-partners-with-cirm/

We will be uniting stem cell biology students and professionals this Friday for the annual Stem Cell Scholars Symposium. The event will provide opportunities both forresearchers to present their work and for students to attend and learn more about stem cell biology. Shout-out to the event's organizer, Inland Empire Stem Cell Consortium, which is comprised of four institutions: CSUSB; UC Riverside Loma Linda University Health, and Western University of Health Sciences. Department of Biology alumna Nicole Lee Sparks, an assistant professor at University of California, Irvine's Department of Environmental and Occupational Health, will serve as one of the event's keynote speakers. CSUSB SSSCR California Institute for Regenerative Medicine
is now home to one of the state regenerative medicine institute’s network of Alpha Clinics, charged with accelerating the development of promising and and expanding patient access to them through clinical trials.

With an $8 million grant from the California Institute for Regenerative Medicine, the UCI Alpha Clinic will lead cell and gene therapy efforts within the university’s academic health system and in close collaboration with academic partners in a four-county area.

“Our unique focus on cell and gene therapy clinical trials for neurological diseases and cancer will increase access for our patients and empower us to lead the way in bringing novel regenerative treatments into the Alpha Clinics Network,” said Dr. Daniela A. Bota, director of the UCI Alpha Clinic director, principal investigator of the CIRM grant and vice dean for research at the UCI School of Medicine.

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October is National Breast Cancer Awareness Month - a time to honor those who lost their lives to this disease and also celebrate our courageous survivors like Dr. Le Ondra Clark Harvey, CEO of CA Council of Community Behavioral Health Agencies and California Institute for Regenerative Medicine board member. Here is more about her story.
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