California Institute for Regenerative Medicine

California Institute for Regenerative Medicine The California Institute for Regenerative Medicine,
California's Cell & Gene Therapy Agency CIRM is California's Stem Cell Agency.
(117)

Our mission is to accelerate world class science to deliver transformative regenerative medicine treatments in an equitable manner to a diverse California and world.

CIRM proudly supported the 2nd Annual ALSP Community Conference, where attendees discussed valuable insights and potenti...
06/26/2024

CIRM proudly supported the 2nd Annual ALSP Community Conference, where attendees discussed valuable insights and potential cell-based therapies for leukodystrophies, a group of rare genetic disorders that affect the central nervous system.

Heidi Edwards of Sisters' Hope Foundation for Hereditary Diffuse Leukoencephalopathy emphasized the importance of such gatherings in bridging gaps between patients, families, and medical professionals. These connections foster hope and understanding.

In addition to funding innovative programs and research that accelerate the development of stem cell and gene therapy treatments, the California Institute for Regenerative Medicine (CIRM) provides …

The first stage of the Neurona Therapeutics clinical trial is supported by CIRM. Investigational therapies that receive ...
06/25/2024

The first stage of the Neurona Therapeutics clinical trial is supported by CIRM. Investigational therapies that receive RMAT designation are eligible to receive expedited development review and planning guidance from the U.S. Food and Drug Administration.

Read the full announcement: https://www.neuronatherapeutics.com/news/press-releases/061824/

With these new awards, CIRM’s now supports more than 100 clinical trials.
06/20/2024

With these new awards, CIRM’s now supports more than 100 clinical trials.

The California Institute for Regenerative Medicine (CIRM) recently approved nearly $31 million in funding, further cementing our commitment to advancing the field of regenerative medicine. This sub…

We're excited to partner with Lineage Cell Therapeutics on the 2nd Annual SCI Investor Symposium! We're looking forward ...
06/20/2024

We're excited to partner with Lineage Cell Therapeutics on the 2nd Annual SCI Investor Symposium! We're looking forward to hearing from our very own Lila Collins and discussing the most recent advancements and future trends for treating spinal cord injuries.

Register to attend at https://scisymposium.com/

“Kids shouldn't have to put their future on hold,” says Evie Junior, who was born with sickle cell disease. After partic...
06/19/2024

“Kids shouldn't have to put their future on hold,” says Evie Junior, who was born with sickle cell disease.

After participating in a CIRM-funded clinical trial at UCLA, Evie stopped experiencing sickle cell pain crises and now has a renewed sense of hope.

This , read Evie’s story and learn how you can champion change for sickle cell in California: https://bit.ly/tackling-scd-from-within

June 19 is World Sickle Cell Awareness Day, an international day observed annually to increase public knowledge about si...
06/19/2024

June 19 is World Sickle Cell Awareness Day, an international day observed annually to increase public knowledge about sickle cell disease (SCD).

To date, CIRM has awarded over $65 million for sickle cell research, from basic discovery to clinical trials. We've launched "Championing Change for Sickle Cell in California" to raise awareness and support for this research.

Learn more at cirm.ca.gov/sickle-cell

This  , join the Cayenne Wellness Center and Children's Foundation and the Sickle Cell Community Consortium at the 5th A...
06/18/2024

This , join the Cayenne Wellness Center and Children's Foundation and the Sickle Cell Community Consortium at the 5th Annual 24-hour World Sickle Cell (SCD) Day Zoom-A-Thon.

People from all over the world will take time on this day to raise SCD awareness. https://www.sicklecellday.com/

To date, CIRM’s educational and training programs have supported 3,800 interns and fellows, the majority of whom have ac...
06/13/2024

To date, CIRM’s educational and training programs have supported 3,800 interns and fellows, the majority of whom have achieved employment or chose to pursue further education in regenerative medicine or related fields.

Photos courtesy of Rashi Ranjan Each year, interns and trainees from the California Institute for Regenerative Medicine (CIRM) education and training programs celebrate achievements, whether that’s…

CIRM was proud to co-sponsor, attend, and participate in UCLA TDG's    Conference last week. Check out this event recap ...
05/30/2024

CIRM was proud to co-sponsor, attend, and participate in UCLA TDG's Conference last week. Check out this event recap highlighting CIRM speakers and our impact in the Los Angeles region.

The California Institute for Regenerative Medicine (CIRM) proudly participated in and sponsored the recent 2024 Los Angeles Bioscience Ecosystem Summit Twenty (LABEST) Conference, the premier showc…

 : Please join us on Saturday, June 1, at 1 PM (PST) for the UCSF Sickle Cell Center of Excellence Gene Therapy Town Hal...
05/29/2024

: Please join us on Saturday, June 1, at 1 PM (PST) for the UCSF Sickle Cell Center of Excellence Gene Therapy Town Hall, hosted by the UCSF Alpha Clinic.

This virtual event is valuable for patients, families, providers, and researchers. Attendees will learn about the science behind current gene therapies, treatment logistics, resources, and what it is like to receive these treatments first-hand from other past patients. Register to attend at https://ucsf.zoom.us/webinar/register/WN_pwqYxTjLTCSsTejGdbBfyQ #/registration

May is Mental Health Awareness Month, and at CIRM, we are providing $1.5 billion to support innovative research and the ...
05/28/2024

May is Mental Health Awareness Month, and at CIRM, we are providing $1.5 billion to support innovative research and the development of cutting-edge therapies for central nervous system (CNS) disease and neuropsychiatric disorders.

Since 1949, Mental Health Awareness Month has been observed in May each year to increase awareness of the importance of mental health and wellness in America.   In California, it is estim…

Hayley Lam, PhD, CIRM Associate Director of Portfolio Development and Review, spoke earlier this month at the American S...
05/28/2024

Hayley Lam, PhD, CIRM Associate Director of Portfolio Development and Review, spoke earlier this month at the American Society of Gene & Cell Therapy 2024 Conference ( ) about incorporating DEI principles into the grant review process and developing gene and cell therapies with a DEI forward approach.

ASGCT interviewed Dr. Lam about DEI and how CIRM prioritizes DEI in our grant review processes.

At , Dr. Lam (CIRM) spoke during a symposium on developing CGTs with a DEI-forward approach. In this interview, she talks about incorporating DEI into the review criteria for CIRM's funded programs, how to measure DEI, and what she'd like to see in the long term for patients. Meeting regis...

CIRM joined Bay Area Community Health Advisory Council's Soul Stroll this weekend—an amazing display of a community's de...
05/21/2024

CIRM joined Bay Area Community Health Advisory Council's Soul Stroll this weekend—an amazing display of a community's dedication to health and wellness.

This year's theme, “Movement is Resistance,” symbolizes a collective effort to combat health disparities in communities of color. Movement is a powerful tool for community wellness and a catalyst in advocating for equity in care. With around 500 community members showing their support and advocating for healthcare equity, it was a great space for CIRM to be and share how we are committed to funding research in disease areas disproportionately affecting communities of color, including sickle cell disease.

To learn more about our commitment to Championing Change for Sickle Cell, visit this page on our website: www.cirm.ca.gov/sickle-cell-disease/

05/20/2024

To date, CIRM has funded 106 clinical trials. This progress is thanks to the dedicated clinical research professionals who make the work possible and pioneering patients who advance discoveries for cell and gene therapies.

This , we recognize their many contributions to the field of regenerative medicine. www.cirm.ca.gov/clinical-trials

05/16/2024

We don't normally , but we wanted to highlight our time with the Parkinson's Disease (PD) community at the Parkinson's Foundation's Moving Day in San Francisco earlier this month.

We had a wonderful time connecting with families, caregivers, and other community organizations who are as dedicated to raising PD awareness as we are.

Sickle cell disease (SCD) affects around 100,000 Americans, 7% of whom are Californians. SCD predominantly impacts the A...
05/14/2024

Sickle cell disease (SCD) affects around 100,000 Americans, 7% of whom are Californians. SCD predominantly impacts the African-American and Hispanic communities, and despite decades of research, the average life expectancy has dropped from 42 in 1995 to 39 today.

It's imperative to better understand SCD and translate those discoveries into new patient therapies. CIRM has invested over $65 million in understanding the disease and developing new treatments. Let's strive for better outcomes together. https://www.cirm.ca.gov/sickle-cell-disease/

ICYMI: Some of our team attended the Parkinson's Foundation   event in San Francisco on May 4. Check out this great reca...
05/10/2024

ICYMI: Some of our team attended the Parkinson's Foundation event in San Francisco on May 4. Check out this great recap of the event by our Outreach Manager, Aditi Desai.

Crissy Field was filled with vibrant colors and massive energy for the 10th annual Moving Day San Francisco event on Saturday, May 4th. Even with the rain and wind, community members showed up to …

A British toddler has had her hearing restored after participating in a pioneering gene therapy trial, marking progress ...
05/10/2024

A British toddler has had her hearing restored after participating in a pioneering gene therapy trial, marking progress in potentially using a gene therapy to treat deafness.

Opal Sandy can hear almost perfectly after groundbreaking surgery that took just 16 minutes

CIRM awarded $1.5 million to a new research project led by Michael Wells, PhD, of UCLA. This research uses stem cell-bas...
05/08/2024

CIRM awarded $1.5 million to a new research project led by Michael Wells, PhD, of UCLA. This research uses stem cell-based "cell village" to identify the genetic and molecular risk factors underlying disease-causing viral infections in diverse populations.

These cell villages are composed of cells that capture the immense diversity of racial and ethnic groups across California, creating an environment for comprehensive analysis of genetic variants and cellular characteristics.

This research has the potential to impact health disparities and advance future antiviral drug development.

Image of Michael Wells, PhD from UCLA The California Institute for Regenerative Medicine (CIRM) recently awarded $1.5 million to a new research project led by Michael Wells, PhD, of UCLA, that aims…

Our team recently attended the amazing   event in San Francisco, organized by .We had a blast connecting with all the wo...
05/06/2024

Our team recently attended the amazing event in San Francisco, organized by .

We had a blast connecting with all the wonderful people and organizations dedicated to raising awareness and support for Parkinson’s disease. The team had the opportunity to highlight the cell and gene therapy research we’ve funded—more than $75 million to date—to help find treatments for those affected by the disease.

Come rain or shine, we are always committed to raising awareness of regenerative medicine and the work we do on behalf of all Californians.

CIRM recently awarded $1.5 million to Denise Al Alam, PhD of The Lundquist Institute, to study lung disease in individua...
05/06/2024

CIRM recently awarded $1.5 million to Denise Al Alam, PhD of The Lundquist Institute, to study lung disease in individuals with chromosome Trisomy 21, also known as Down Syndrome.

In California, 667 babies are born with Down Syndrome every year, and Trisomy 21 affects multiple organ systems; respiratory complications are a major cause of death in both children and adults with this genetic condition.

Dr. Al Alam and her team of researchers hope to uncover the genes and pathways associated with the respiratory defects associated with Trisomy 21, paving the way for targeted therapeutic approaches.

Stock image of the Trisomy 21 chromosome The California Institute for Regenerative Medicine (CIRM) recently awarded $1.5 million to Denise Al Alam, PhD, of the Lundquist Institute for Biomedical In…

We were excited to sponsor and attend   and see our very own VP of Scientific Programs, Rosa Canet-Aviles, PhD, speak on...
05/03/2024

We were excited to sponsor and attend and see our very own VP of Scientific Programs, Rosa Canet-Aviles, PhD, speak on the educational and training programs we fund across California.

"We are creating a comprehensive network with real-world training opportunities. This is toward the realization of our mission." - Rosa Canet-Aviles, PhD

In April, the California Institute for Regenerative Medicine (CIRM) collaborated with the  and the Alpha Clinics Network...
05/01/2024

In April, the California Institute for Regenerative Medicine (CIRM) collaborated with the and the Alpha Clinics Network to host the Regenerative Medicine Nurse Training Symposium.

With nearly 200 attendees, in person and virtually, the symposium aimed to equip nurses with skills essential for supporting patients in regenerative medicine clinical trials. CIRM’s Alpha Clinics, renowned for stem cell and gene therapy trials, contributed educational materials.

The symposium fostered networking, knowledge exchange, and professional growth among attendees. Participants expressed appreciation for the insights gained, enhancing their ability to provide high-quality care in the evolving landscape of regenerative medicine.

Click the link 🔗 in our bio for a full recap of the event on our official blog.

In April, the California Institute for Regenerative Medicine (CIRM) collaborated with the City of Hope and the Alpha Cli...
05/01/2024

In April, the California Institute for Regenerative Medicine (CIRM) collaborated with the City of Hope and the Alpha Clinics Network to host the Regenerative Medicine Nurse Training Symposium.

With nearly 200 attendees, in person and virtually, the symposium aimed to equip nurses with skills essential for supporting patients in regenerative medicine clinical trials. CIRM's Alpha Clinics, renowned for stem cell and gene therapy trials, contributed educational materials.

The symposium fostered networking, knowledge exchange, and professional growth among attendees. Participants expressed appreciation for the insights gained, enhancing their ability to provide high-quality care in the evolving landscape of regenerative medicine. Read our blog for a full recap of the event.

Regenerative medicine is a rapidly evolving field. As more therapies reach commercialization and clinical trial stages, there remains an immediate need to equip direct patient care nurses with skil…

CIRM has approved awarding $31 million for clinical trial research.The awards will support clinical research at Luxa Bio...
04/26/2024

CIRM has approved awarding $31 million for clinical trial research.

The awards will support clinical research at Luxa Biotechnolgy to find a cell treatment for dry age-related macular degeneration (AMD), a condition impacting almost 19.8 million people in the United States.

The awards will also help fund a multi-site trial led by UCSF exploring the potential of a gene therapy targeting cancers that form in the brain and spinal cord.

Additionally, a $15 million award to Allogene Therapeutics will support the development of a CAR-T cell product designed to treat metastatic clear cell renal cell carcinoma, the most common kidney cancer. https://bit.ly/cirm-pressreleases

04/18/2024

CIRM awarded $56 million in February to advance clinical research on Parkinson's disease, autoimmune conditions, and various cancers. Seven projects, from preclinical research to clinical trials, were approved for funding.

Notable projects include an $8 million award to Aspen Neuroscience for a groundbreaking dopaminergic neuron replacement therapy for Parkinson's disease and a $7.9 million award to Fate Therapeutics to advance a CD19 CAR T-cell therapy for Systemic Lupus Erythematosus.

Additionally, a $5.3 million award was granted to City of Hope for late-stage preclinical research focusing on a neural stem cell-mediated treatment for chemo-resistant ovarian cancer, furthering CIRM's commitment to pioneering medical breakthroughs.

Read for more: https://bit.ly/cirm_thestemcellar

CIRM is committed to equitable access to clinical trials in California. That's why we've approved awarding $2.5 million ...
04/17/2024

CIRM is committed to equitable access to clinical trials in California.

That's why we've approved awarding $2.5 million to Eversana to launch a Patient Support Program (PSP) to alleviate barriers like financial constraints and logistical hurdles.

Our commitment is to advance transformative therapies, ensuring every Californian benefits from breakthroughs in regenerative medicine.

Hataalii Tiisyatonii Begay (HT) participated in a CIRM-funded clinical trial at UCSF for Artemis-SCID, a condition that can be life-threatening or fatal. Photo courtesy Barbara Ries / UCSF. The Ca…

The California Institute for Regenerative Medicine (CIRM) is championing change in Sickle Cell Disease research in partn...
04/16/2024

The California Institute for Regenerative Medicine (CIRM) is championing change in Sickle Cell Disease research in partnership with patients, patient advocates, researchers, and community partners including, , , , , , , , and .

To date, CIRM has invested more than $65 million towards research for sickle cell, ranging from basic discovery to clinical trials.

Click the link 🔗 in our bio and read our latest blog to learn more about this condition that affects more than 100,000 Americans and 20 million people worldwide.

The California Institute for Regenerative Medicine (CIRM) is championing change in Sickle Cell Disease research in partn...
04/16/2024

The California Institute for Regenerative Medicine (CIRM) is championing change in Sickle Cell Disease research in partnership with patients, patient advocates, researchers, and community partners, including Axis Advocacy for Sickle Cell Disease, Sickle Cell 101, UCSF, All of Us Research, Global Genes, National Organization for Rare Disorders, Inc. (NORD), Cayenne Wellness Center and Children's Foundation, and West Fresno Family Resource Center.

To date, CIRM has invested more than $65 million towards research for sickle cell, ranging from basic discovery to clinical trials.

Visit our web page to explore CIRM-funded sickle cell clinical trials, download resources to spread awareness, and learn more about this condition that affects more than 100,000 Americans and 20 million people worldwide.

The California Institute for Regenerative Medicine (CIRM), established by the voters of California, is accelerating research and awareness of Sickle Cell Disease. The California Institute for Regen…

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Accelerating Stem Cell Treatments to Patients

Our mission at CIRM is to accelerate stem cell treatments to patients with unmet medical needs by funding promising stem cell research in California.

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