06/09/2026
Twenty Years After the Anthrax Terrorist Attacks of 2001: Lessons Learned and Unlearned for
the COVID-19 Response
Summary by Zilmarie Díaz Pacheco, MD
UMass Disaster Medicine Fellow
This article describes the health system before the 2001 anthrax attacks, the response to these attacks, Influenza A (H1NI), Ebola, and Zika response in the following years, and how lessons
learned were unlearned during the COVID-19 response. Before 2001, there was limited capacity for coordination and surge response, and the health system was unprepared to diagnose and treat novel pathogens effectively. This improved during the response to the anthrax attacks, resulting in patient surge plans, interoperable communication systems, hospital evacuation
plans, and healthcare coalitions. This led to the Pandemic and All-Hazards Preparedness Act, the Model State Emergency Health Powers Act, and the National Strategic Stockpile, among
other programs. Influenza A(H1N1) was the first major test of these programs, and they seemed to pay off. After this response, emergency preparedness waned, and the same could not be said
about the Ebola and Zika virus response. By 2020, federal preparedness and public health funding had decreased significantly. The American Rescue Plan Act of 2021 had to be
established for testing, contract tracing, and mitigation. The SNS had not been replenished, leading to PPE shortages. Emergency protocols, such as mask and vaccine mandates, became
politically divisive, leading to a weakening of public health powers. The authors conclude by emphasizing the need to build core public health and hospital capacities, replenishing the SNS,
and strategic planning for further responses.
Gostin LO, Nuzzo JB. Twenty Years After the Anthrax Terrorist Attacks of 2001: Lessons Learned and Unlearned for the COVID-19 Response. JAMA. 2021 Nov 23;326(20):2009-2010. doi: 10.1001/jama.2021.19292. PMID: 34705048.